| January 2 | Spain recaptures Granada from the Moors (Granada Day) |
| January 23 | "Pentateuch" (Jewish holy book) 1st printed |
| March 21 | Alonzo Pietro, pilot, sailed with Columbus |
| March 30 | King Ferdinand and Queen Isabella sign decree expelling Jews from Spain |
| March 31 | Queen Isabella of Castilia and Ferdinand of Aragon expels Jews |
| April 17 | Christopher Columbus signs contract with Spain to find Indies |
| April 30 | Columbus is given royal commission to equip his fleet |
| April 30 | Spain announces it will expels all Jews |
| May 15 | Cheese and Bread rebellion: German mercenaries kills 232 Alkmaarse |
| August 2 | Jews are expelled from Spain by King Ferdinand and Queen Isabella |
| August 3 | All Jews are expelled from Spain |
| August 3 | Columbus sets sail from Palos, Spain for "Indies" |
| August 11 | Rodrigo de Borja becomes Pope Alexander VI |
| September 6 | Columbus' fleet leaves Gomera, Canary islands |
| September 9 | Columbus' fleet sets sail west |
| September 25 | Crewman on Pinta sights "land"-a few weeks early |
| October 2 | King Henry VII of England invades France |
| October 7 | Columbus misses Florida when he changed course |
| October 8 | Columbus' fleet about 400 sea miles from Puerto Rico |
| October 11 | Columbus' ships sites land on the horizon (Bahamas) |
| October 12 | Columbus arrives in Bahamas |
| October 12 | Flemish rebel leader Philip van Kleef surrenders |
| October 13 | English Admiral Poynings fleet occupies Lock |
| October 14 | Columbus leaves San Salvador; arrives in Santa Maria of Concepcion |
| October 16 | Columbus' fleet anchors at "Fernandina" (Long Island, Bahamas) |
| October 17 | Columbus sights isle of San Salvador (Watling Island, Bahamas) |
| October 19 | Columbus sites "Isabela" (Fortune Island, Bahamas) |
| October 21 | Columbus lands on San Salvador Island |
| October 21 | Columbus' discovers America (Oct 12, 1492 Julian calender) |
| October 24 | 24 Jews are burned at stake in Mecklenburg Germany |
| October 25 | Christopher Columbus and ship Santa Maria land in Dominican Republic |
| October 25 | Columbus' fleet sites "Zandislands" (Ragged Island Range, Bahamas) |
| October 25 | Columbus' ship Santa Maria lands at Dominican Republic |
| October 26 | Columbus' fleet anchors on Ragged Island Range, Bahamas |
| October 26 | Lead pencils 1st used |
| October 27 | Christopher Columbus discovers Cuba and claims it for Spain |
| November 5 | Christopher Columbus learns of maize (corn) from Indians of Cuba |
| November 9 | Peace of Etaples (Henry VII and Charles VIII) |
| November 15 | Christopher Columbus notes 1st recorded reference to tobacco |
| November 15 | In Spain, 6 Jews and 5 Conversos are accused of using black magic |
| November 21 | Pinta under Martin A Pinzon separates from Columbus' fleet |
| December 5 | Columbus discovers Hispaniola (El Espanola/Haiti) |
| December 6 | Haiti discovered by Columbus, at Mole Saint Nicolas |
| December 25 | Columbus' ship Santa Maria docks at Dominican Republic |
| December 26 | 1st Spanish settlement in New World founded, by Columbus |
| December 31 | 100,000 Jews expelled from Sicily |
