| January 4 | Columbus left new world on return from 1st voyage |
| January 9 | 1st sight of manatees by Christopher Columbus |
| January 12 | Last day for all Jews to leave Sicily |
| January 16 | Columbus returns to Spain on his 1st trip |
| January 19 | France cedes Roussillon and Cerdagne to Spain by treaty of Barcelona |
| March 15 | Christopher Columbus returns to Spain after 1st new world voyage |
| May 4 | Spanish Pope Alexander VI divides America between Spain and Portugal |
| May 23 | King Charles VIII and Maximilian I of Austria signs Peace of Senlis |
| August 19 | Maximilian I of Austria becomes Roman Catholic German emperor |
| September 24 | Columbus' 2nd expedition to New World |
| September 25 | Columbus sails with 17 ships on 2nd voyage to America |
| October 30 | Christopher Columbus discovers island of Dominica |
| November 3 | Christopher Columbus discovers island of Dominica |
| November 11 | Columbus discovers Saba |
| November 19 | Christopher Columbus discovers Puerto Rico, on his 2nd voyage |
