| January 28 | Pope gives his son Cesare Borgia as hostage to Charles VIII of France |
| February 22 | French King Charles VIII enters Naples to claim crown |
| May 20 | French King Charles VIII leaves Naples |
| May 31 | Emperor Maximilian, Pope Alexander VI, Milan, King Ferdinand, Isabella and Venice sign anti-French Saint League |
| June 1 | 1st written record of Scotch Whiskey appears in Exchequer Rolls of Scotland, Friar John Cor is the distiller |
| July 6 | Battle at Fornovo, French king Charles VIII beats St. League |
| July 7 | King Ferdinand II returns to Naples |
| July 20 | French viceroy of Naples Montpensier surrenders |
| November 27 | Scottish king James IV receives bedrieger Perkin Warbeck |
