| January 6 | Jews are expelled from Graz (Syria) |
| February 25 | Italians troops reconquer Taranto on France |
| March 9 | Nicolaus Copernicus 1st recorded astronomical observation, |
| May 2 | John Cabot departs to North-America |
| May 10 | Italian navigator Amerigo Vespucci leaves for 1st voyage to New World |
| May 13 | Pope Alexander VI excommunicates Girolamo Savonarola |
| June 22 | Antitax insurrection in Cornwall suppressed at Blackheath |
| June 24 | John Cabot claims eastern Canada for England (believes he found Asia in Nova Scotia) |
| July 8 | Vasco da Gama departs for trip to India |
| July 26 | "Edward IV's son" Perkin Warbecks army lands in Cork |
| August 6 | John Cabot returns to Bristol from North-America |
| August 10 | John Cabot tells King Henry VII of his trip to "Asia" |
| September 7 | Sailor Perkin Warbeck becomes English King Richard IV |
| November 18 | Vasco da Gama reached the Cape of Good Hope |
| November 22 | Portuguese navigator Vasco da Gama rounds Cape of Good Hope |
