| March 2 | Vasco da Gama's fleet visits Mozambique Island |
| April 7 | Crowd storms Savonarola's convent San Marco Florence, Italy |
| May 20 | Portuguese explorer Vasco da Gama arrives at Calicut, India |
| May 30 | Columbus departs with 6 ships for 3rd trip to America |
| June 21 | Jews are expelled from Nurenberg Bavaria by Emperor Maximillian |
| June 26 | Toothbrush invented |
| July 7 | Emperor Maximilian I establishes choir of Imperial Chapel |
| July 20 | Emperor Maximilian names Albrecht governor of Netherlands |
| July 31 | Christopher Columbus discovers island of Trinidad |
| August 1 | Christopher Columbus lands on "Isla Santa" near Venezuela |
| August 7 | Columbus arrives in Caribbean |
| August 14 | Columbus landed at the mouth of the Orinoco River in Venezuela |
| August 17 | Cardinal Borgia renounced his vows and office to marry a French princess |
