| January 5 | Duke Ludovico Sforza's troops reconquer Milan |
| March 9 | Pedro Cabral departs with 13 ships to India |
| April 8 | Battle at Novara: King Louis XII beats duke Ludovico Sforza |
| April 10 | France captures duke Ludovico Sforza of Milan |
| April 22 | Pedro Alvarez Cabral discovers Brazil and claims it for Portugal |
| April 23 | Pedro Cabral lands and annexes Brazil (Terra da Vera Cruz) |
| June 25 | Pope Alexander VI accept Treaty of Granada |
| July 15 | "Blood Wedding" of Astorre Baglione and Lavinia Colonna in Perugia family Baglione massacre |
| July 15 | Duke Albrecht of Saxon beats Friese rebellion |
| August 10 | Diego Diaz discovers Madagascar |
| November 11 | Treaty of Granada: France and Aragon divide Naples |
| November 25 | Governor De Bobadilla of Santo Domingo captures Columbus |
