| January 1 | Portuguese navigators discover Rio de Janeiro |
| February 25 | Austrian emperor Maximilian I reformats government machine |
| March 11 | Tebriz, shah Ismail I of Persia crowned |
| May 9 | Columbus left Spain on his 4th and final trip to New World |
| May 11 | Columbus begins 4th and last trip to "Indies" |
| May 21 | Portuguese Admiral Da Nova discovers St. Helena |
| June 19 | Emperor Maximilian I and England sign treaty of Antwerp |
| August 8 | Jacobus IV of Scotland marries Margaretha Tudor |
| September 18 | Christopher Columbus lands at Costa Rica on his 4th and last voyage |
| October 16 | Storm ravages Friese coast |
| December 31 | Cesare Borgia (son of pope Alexander VI) occupies Urbino |
