| January 20 | Casa Contratacion (Board of Trade) found (Spain) to deal with American affairs |
| February 18 | Henry Tudor created Prince of Wales (later Henry VIII) |
| April 28 | Battle at Cerignalo: Spanish army under G Cordoba beats France |
| May 10 | Columbus discovers Cayman Islands |
| October 30 | Queen Isabella of Spain bans violence against indians |
| November 11 | Pope Julius II elected |
| December 27 | Battle at Garigliano, Spanish army under G Cordoba beats France |
| December 29 | Battle at Carigliano: Spanish army beats France |
