| March 18 | Emperor Maximilian I names Margaretha land guardians of Netherlands |
| April 7 | France declares war on Venice |
| April 16 | French army under Louis XII enters Alps |
| April 21 | Henry the VIII becomes King of England |
| April 22 | Henry VIII ascended to throne of England |
| April 27 | Pope Julius II excommunicates Italian state of Venice |
| May 14 | Battle of Agnadello, French beat Venitians in Northern Italy |
| June 3 | Henry VIII married wife No 1, Catherine of Aragon |
| June 11 | King Henry VIII marries wife #1 Catharina of Aragon |
| June 24 | Henry VIII crowned King of England |
| July 17 | Venice recaptures Padua |
| September 27 | Storm ravages Flemish/Dutch/Friese coast, 1000s killed |
| October 12 | Emperor Maximilian leaves Italy |