| February 5 | French troops under Gaston de Foix rescues Bologna |
| February 16 | Battle at Valeggio: French troops beat Venetianen |
| February 19 | French troops under Gaston de Foix occupy Brescia |
| April 10 | Pope Julius II opens 5th Council of Lateranen |
| April 11 | Battle at Ravenna: France under Gaston de Foix beat Spanish Army |
| May 3 | 5th Lateran Council (18th ecumenical council) opens in Rome |
| May 3 | Pope Julius II opens 5th Council of Lateranen |
| August 10 | Battle at Brest: English fleet beats France |
| November 1 | Michelangelo's paintings on ceiling of Sistine Chapel, 1st exhibited |
| November 7 | Medici's discharge Niccolo Machiavelli from Florence |
