| January 20 | Christian II succeeds Johan I as Danish/Norwegian king |
| March 11 | Giovanni de' Medici chosen Pope Leo X |
| March 27 | Spaniard Juan Ponce de Leon discovers Florida |
| April 2 | Florida discovered, claimed for Spain by Ponce de Leon |
| April 8 | Explorer Juan Ponce de Leon claimed Florida for Spain |
| June 6 | Battle at Novara: Habsburgers vs Valois |
| August 16 | Battle at Eguinegatte/Guinegate: Maximilian and Henry III beat France |
| September 9 | Battle of Flodden Fields; English defeat James IV of Scotland |
| September 23 | King Henry III and Emperor Maximilian conquer Doornik |
| September 25 | Vasco Nunez de Balboa is 1st European to see Pacific Ocean |
