| January 1 | Francois, Duke of Angoulame succeeds Louis XII as Francois I of France |
| January 1 | Jews are expelled from Laibach Austria |
| May 3 | Persian Gulf: Portugese fleet occupies Ormuz |
| May 19 | George van Saksen-Meissen sells Friesland for 100,000 gold guilders to arch duke Charles |
| July 22 | Anna of Bohemia (12) marries Karel van Ferdinand of Austria |
| July 22 | Congress of Vienna settles issues between Poland and Holy Roman Empire |
| July 22 | Louis of Hungary (9) marries Maria of Bohemia and succession to Hungarian throne |
| September 13 | Battle at Marignano: France beats Habsburgers and Pope Leo X |
| September 14 | Battle at Marignano ends in French/Venetian victory |
| December 24 | Thomas Wolsey appointed English Lord Chancellor |
