| January 22 | Turks conquer Cairo |
| March 16 | Pope Leo X signs 5th Council of Lateranen |
| April 13 | Osmaanse army occupies Cairo |
| May 19 | Philip van Bourgondie installed as bishop of Utrecht |
| June 11 | Sir Thomas Pert reaches Hudson Bay |
| July 1 | 1st burning of Protestants at stake in Netherlands |
| July 1 | Inquisitor Adrian Boeyens (pope Adrianus VI) becomes cardinal |
| July 9 | Gelderse crowd robber murders population of Asperen |
| October 31 | Luther posts 95 theses on Wittenberg church-Protestant Reformation |