| January 4 | 1st Altenburger sermon (Luther and Karl von Miltitz) |
| March 13 | Cortez lands in Mexico |
| May 9 | Austrian adel/burgerij in uprising against central government |
| June 28 | King Carlos I elected Roman Catholic German emperor Charles V |
| July 16 | Public debate between Martin Luther and theologist John Eck |
| July 25 | San Cristobal de la Habana forms in Cuba |
| July 26 | Pizarro receives royal charter for South American west coast |
| August 10 | Magellan's 5 ship set sail to circumnavigate Earth |
| August 15 | Panama City founded |
| September 2 | 1st Battle of Tehuacingo, San Salvador vs Mexico |
| September 5 | 2nd Battle of Tehuacingo, Mexico: Hernan Cortes vs Tlascala Aztecs |
| September 20 | Ferdinand Magellan starts 1st successful circumnavigation of world |
| November 4 | Flood ravages Dutch/Friese coast |
| November 7 | University of Leuven convicts teaching of Luther |
| November 8 | 1st meeting of Montezuma and Hernando Cortes in Mexico |
