| January 18 | Christian II of Denmark and Norway defeats Swedes at Lake Asunde |
| June 6 | France and England sign treaty of Scotland |
| June 30 | Spanish conquerors under Cortes take gold from Aztecs |
| July 10 | King Charles V and King Henry VIII signs treaty of Calais |
| July 14 | Battle of Otumba Mexico: Hernan Cortes and Tlascala's vs Aztecs |
| September 30 | Suleiman I succeeds his father Selam I as sultan of Turkey |
| October 7 | 1st public burning of books in Netherlands, in Louvain |
| October 15 | King Henry VIII of England orders bowling lanes at Whitehall |
| October 21 | Ferdinand Magellen arrives at Tierra Del Fuego (Pacific Ocean) |
| October 23 | King Carlos I crowned, German emperor Charles V |
| November 4 | Danish/Norwegian king Christian II crowned king of Sweden |
| November 9 | Swedish King Christian II executes 600 nobles |
| November 20 | Friesland hit by heavy hail storm |
| November 28 | Ferdinand Magellan begins crossing Pacific Ocean |
| December 10 | Martin Luther publicly burned papal edict demands he recant |
