| March 19 | Giovanni de Varrazano of France sights land around area of Carolinas |
| April 17 | Giovanni Verrazano, a florentine navigator, discovers New York Bay |
| April 19 | Pope Clemens VII fires Netherlands inquisitor-general French Van de Holly |
| April 24 | Duke of Bourbon drives Admiral Bonnivet out of Milan |
| May 20 | Duke of Albany leaves Scotland |
| June 27 | Earl Henry III of Nassau weds Mencia de Medoza, 16-years old marquess |
| June 28 | Duke van Bourbon occupies Province |
| July 15 | Emperor Karel I bans German national synode |
| July 19 | Boer War begins in Germany's Black Forest |
| July 26 | James I (12) becomes king of Scotland |
| August 19 | Emperor Charles V's troops besieges Marseille |
| September 29 | Emperor Charles V's troops give siege of Marseille |
| October 26 | Spanish troops give Milan to France |
| November 14 | Pizarro's begins 1st great expedition, near Colombia |
| December 12 | Pope Clement VII approves Organization of Jewish Community of Rome |
