| February 24 | Ferdinand of Austria crowned as king of Bohemia |
| March 16 | Battle at Khanua: Mogol Emperor Babur beats Rajputen |
| April 30 | England and France sign treaty of Westminster |
| May 6 | Spanish and German Imperial troops sack Rome; ending Renaissance |
| May 16 | Florence becomes a republic |
| May 17 | Panfilo de Narvaez departs to explore Florida |
| May 30 | University of Marburg (Germany) founded |
| June 7 | Pope Clement VII surrenders to emperor Charles V's armies |
| June 24 | Gustaaf I begins Reformation in Sweden, taking RC possessions |
| November 3 | Ferdinand of Austria/Bohemia chosen as king of Hungary |
| November 26 | Pope Clemens VII signs treaty with emperor Karel I |
| December 6 | Pope Clemens VII fleas to Orvieto |
| December 12 | Composer Adrian Willaert moves from Milan to Venice |
