| January 22 | England and France declare war on Emperor Charles V |
| February 12 | Treaty of Dordrecht between emperor and ecclesiastical power |
| February 24 | Hungarian anti-king Janos Zapolyai and Sultan Suleiman signs treaty |
| March 5 | Utrecht governor Maarten van Rossum plunders The Hague |
| May 1 | Panfilo the Narvaez begins exploration to with 350 men to Florida |
| June 30 | Burgundy army occupies Utrecht |
| September 28 | Spanish fleet sinks in Florida hurricane; about 380 die |
| October 20 | Treaty of Gorinchem (Emperor and church) |
