| January 5 | Pope Clemens VII forbids English king Henry VIII to re-marry |
| January 16 | English Reformation parliament's 2nd sitting |
| January 26 | Lisbon hit by Earthquake; about 30,000 die |
| January 31 | Kings Ferdinand of Austria/Janos Zapolyai of Hungary accept each other |
| February 11 | Henry VIII recognized as supreme head of Church in England |
| February 26 | Earthquake in Lisbon Spain, kills 20,000-30,000 |
| February 27 | Evangelical German monarchy/towns form Schmalkaldische Union |
| May 31 | "Women's Revolt" in Amsterdam: wool house in churchyard aborted |
| June 9 | Pope Clemens VII and Francois I sign secret treaty against Karel V |
| October 11 | Battle at Kappel: Swiss RC kantons beat protestant |
| October 24 | Bavaria joins Schmalkaldische Union |
