| March 18 | English parliament bans payments by English church to Rome |
| April 26 | Sultan Suleiman through Hungary on away to Vienna |
| May 16 | Sir Thomas More resigns as English Lord Chancellor |
| June 23 | Henry VIII and Francois I signs secret treaty against emperor Karel V |
| July 23 | Karel I and evangelical monarchy signs Peace of Neurenberg |
| November 2 | Zealand/South Holland flooded |
| November 15 | Pope Clemens VII tells Henry VIII to end relationship with Anna Boleyn |
| November 16 | Pizarro captures Incan emperor Atahualpa after victory at Cajamarca |
