| January 25 | England's King Henry VIII marries Anne Boleyn (approximate date) |
| March 30 | Henry VIII divorces his 1st wife, Catherine of Aragon |
| March 30 | Thomas Cranmer becomes archbishop of Canterbury |
| May 23 | King Henry VIII and Catherine of Aragon marriage declared null and void |
| May 28 | England's archbishop voids King Henry VIII and Anne Boleyn's marriage |
| June 1 | Anna Boleyn crowned queen of England |
| June 22 | Ferdinand of Austria and Sultan Suleiman sign peace treaty |
| July 11 | Pope Clement VII excommunicated England's King Henry VIII |
| August 29 | Francisco Pizarro orders death of last Incan King of Peru, Atahualpa |
| November 15 | Francisco Pizarro arrives at Cuzco |
