| January 6 | City of Lima Peru founded by Francisco Pizarro |
| January 15 | Henry VIII declares himself head of English Church |
| January 18 | Francisco Pizarro founds Lima Peru |
| February 10 | 12 nude anabaptists run through Amsterdam streets |
| March 10 | Bishop Tomas de Berlanga discovers Galapagos Islands |
| March 28 | Bloemkamp Abbey (Oldeklooster) attacked and destroyed |
| June 14 | Karel V's fleet sails under Andrea Doria to Tunis |
| June 17 | English Catholic Cardinal John Fischer state rights |
| June 24 | Anabaptists Protestants conquered and disbanded |
| June 24 | Hessische troops occupy Munster |
| July 1 | Sir Thomas More goes on trial in England charged with treason |
| July 14 | Emperor Charles V conquerors Tunis |
| July 22 | Christians captured in Tunis in uprising against Admiral Barbarossa |
| August 15 | Asuncion, Paraguay founded |
| August 31 | Pope Paul II deposed and excommunicated King Henry VIII |
| September 1 | French navigator Jacques Cartier reaches Hochelaga (Montreal) |
| October 2 | Jacques Cartier discovers Mount Royal (Montreal) |
| October 4 | 1st full English translation of the Bible printed in Switzerland |
