| January 17 | Francois Rabelais absolved of apostasy by Pope Paul III |
| February 2 | Pedro de Mendoza finds Argentine city of Buenos Aires |
| February 18 | France and Turkey sign milt/trade agreement against King Karel |
| April 14 | English king Henry VIII expropriate minor monasteries |
| May 2 | King Henry VIII accused Anna Boleyn of adultery and incest |
| May 6 | King Henry VIII, orders bible be placed in every church |
| May 15 | Anna Boleyn and Lord Rochford accused of adultery/incest |
| May 17 | Anne Boleyns 4 "lovers" executed |
| May 23 | Pope Paul III installs Portugese inquisition |
| May 30 | English king Henry VIII marries Jane Seymour |
| June 6 | Mexico begins it's inquisition |
| July 9 | French navigator Jacques Cartier returns to Saint-Malo from Canada |
| July 18 | Pope's authority declared void in England |
| September 8 | Earl of Nassau disbands siege of Peronne |
| October 20 | Danish/Norw king Christian III leads reform in Catholic possessions |
| December 22 | English scholar Reginald Pole appointed cardinal |
