| February 1 | Emperor Karel and King Francois I sign anti-English treaty |
| February 15 | Emperor Charles receives Cardinal Pole in Toledo |
| February 19 | Jews of Tyrnau Hungary (then Trnava, Czechoslovakia), expelled |
| April 19 | Charles, protestant German monarch, signs Treaty of Frankrfurt |
| May 28 | Hernando de Soto lands in Florida |
| May 30 | Spanish explorer Fernando de Soto discovers Florida |
| June 3 | Hernando De Soto claims Florida for Spain |
| October 4 | King Henry VIII and Anna of Kleef marry |
| December 29 | St. Jacobs Church burns after being hit by lightning |
