| January 6 | King Henry VIII of England married his 4th wife, Anne of Cleves |
| February 9 | The 1st recorded race meet in England (Roodee Fields, Chester) |
| February 14 | Emperor Charles V enters Ghent without resistance, executes rebels |
| February 25 | Francisco V squez de Coronado searches for 7 cities of Cibola Mexico |
| March 4 | Protestant count Philip of Hessen marries 2nd wife |
| March 19 | Court of Holland names Amsterdam sheriff John Hubrechtsz a "heretic" |
| April 29 | Emperor Charles declares all privileges of Gent ended |
| May 4 | Venice and Turkey sign Treaty of Constantinople |
| June 3 | Hernando de Soto crosses Appalachian Mountain, 1st European to do so |
| June 10 | Thomas Cromwell arrested in Westminister |
| June 24 | Henry VIII divorces his 4th wife, Anne of Cleves |
| June 29 | English ex chancellor Thomas Cromwell sentenced as heretic |
| July 9 | England's King Henry VIII 6-mo marriage to Anne of Cleves annulled |
| July 23 | Turkey recognizes Janos Sigismund Zapolyai as vassal-king of Hungary |
| July 28 | English King Henry VIII marries Catharine Howard, his 5th wife |
| August 25 | Explorer Hernando de Alarcon travels up Colorado River |
| August 29 | Emperor Karel deprives city Gent definitive rights/privileges |
| September 27 | Pope Paul III recognizes Society of Jesus/Order of the Jesuits |
| September 27 | Society of Jesus (Jesuits) founded by Ignatius Loyola |
| October 2 | Venice/Turkey signs peace |
| October 11 | Emperor Karel names his son Philip, duke of Milan |
