| January 21 | Parliament passes bill of attainder against Queen Katherine Howard |
| June 27 | Juan Rodriguez Cabrillo claims California for Spain |
| July 12 | French troops under Maarten van Rossem occupies Flanders |
| July 21 | Pope Paul III begins inquisition against Protestants (Sactum Officium) |
| August 2 | French troops leave Flanders |
| August 23 | Rabbi Joseph Caro completes his commentary of Tur Code |
| August 24 | Conquistador Francisco de Orellana returns to Spain |
| September 28 | Juan Rodriguez Cabrillo discovers California, at San Diego Bay |
| October 7 | Explorer Cabrillo discovered Catalina Island off California coast |
| November 22 | Spain delegates "New Laws" against slavery in America |
| November 24 | Battle at Solway Moss: English beat Scottish King James |
