| February 11 | Battle at Wayna Daga: Ethiopian/Portugese troops beat Moslem army |
| February 11 | Karel/Henry VIII sign anti-French covenant |
| July 1 | England and Scotland sign Peace treaty of Greenwich |
| July 7 | French troops invade Luxembourg |
| July 12 | England's King Henry VIII weds Catherine Parr (6th and last wife) |
| August 5 | French and Turkish troops occupy Nice |
| August 22 | Emperor Charles V's army occupies Duren |
| September 3 | Cardinal Beaton replaces earl Arran as regent for Mary of Scotland |
| September 6 | French and Turkish fleet occupies Nice |
| September 7 | Duke Willem of Gulik surrenders to emperor Charles V |
| September 12 | Treaty of Venlo: Duke Willem of Gulik and Emperor Charles V |
