| January 25 | Battle at Talikota India: Moslems destroy Vijayanagar's army |
| March 1 | Spanish occupier Estacio de Sa founds Rio de Janeiro |
| April 27 | 1st Spanish settlement in Philippines, Cebu City, forms |
| June 14 | Catharina de Medici and Duke of Alva discuss Calvinism |
| July 29 | Mary Queen of Scots marries her cousin, Henry Stuart, Lord Darnley |
| August 28 | Oldest city in the U.S., St. Augustine Fla, established |
| September 8 | 1st permanent settlement in U.S. forms (St. Augustine, Florida) |
| September 8 | Turkish siege of Malta broken by Maltese and Knights of St. John |
| September 20 | Spaniards capture Fort Caroline Florida and massacre the French |
| November 13 | King Philip II's "Letters out Segovia" reaches Brussels |
| November 13 | Pope Pius IV publishes degree Professi fidei |
| December 24 | Compromise of the Nobles closes against inquisition |
