| February 24 | Claudio Monteverdi's opera "Orfeo," premieres in Mantua |
| April 25 | Battle at Gibraltar: Dutch fleet beats Spanish/Portuguese fleet |
| April 26 | 1st British to establish an American colony land at Cape Henry, Va |
| May 13 | English colonists (John Smith) lands near James River in VA |
| May 14 | 1st permanent English settlement in New World, Jamestown, Virginia |
| June 21 | 1st Protestant Episcopal parish in America established, Jamestown |
| June 25 | Mentally ill emperor Rudolf II signs Treaty of Lieben, giving up Austria, Hungary and Moravia |
| June 30 | Annales Ecclesiastici (Scientific History of Catholicism) published |
| July 7 | "God Save the King" is 1st sung |
