| February 10 | Academie Franeaise forms in Paris (by Cardinal Richelieu) |
| February 13 | Oldest U.S. public institution, Boston Latin School founded |
| April 28 | Virginia Governor John Harvey accused of treason and removed from office |
| May 19 | France declares war on Spain |
| May 28 | Zorilla's "El Desafio de Carlos V," premieres in Madrid |
| May 30 | Emperor Ferdinand II and Saksen sign Peace of Prague |
| June 28 | French colony of Guadeloupe established in Caribbean |
| July 11 | Armies of Savoye/Mantua/Parma occupy Milan |
| July 28 | Spanish marshal Piccolomini conquerors Schenkenschans |
| August 15 | 1st recorded U.S. hurricane hit the Plymouth Colony |
| September 12 | Sweden and Poland sign ceasefire Treaty of Stuhmsdorf |
| September 18 | Emperor Ferdinand II declares war on France |
| October 9 | Religious dissident Roger Williams banished from Mass Bay Colony |
