| February 4 | Oliver Cromwell grants residency to Luis Caravajal |
| March 23 | France and England form alliance against Spain; England gets Dunkirk |
| March 31 | English Humble Petition offers Lord Protector Cromwell the crown |
| April 3 | English Lord Protector Cromwell refuses crown |
| April 20 | Battle in Santa Cruz Bay, Tenerife: English fleet under Robert Blake sinks Spanish silver fleet |
| June 1 | 1st Quakers arrives in New Amsterdam (New York) |
| July 13 | Oliver Cromwell constrains English army leader John Lambert |
| September 19 | Brandenburg and Poland sign Treaty of Wehlau |
| September 24 | 1st autopsy and coroner's jury verdict is recorded in state of Maryland |
| October 1 | Treaty of Raalte: Willem II no longer viceroy of Overijssel |
| October 3 | French troops occupy Mardyke |
| November 6 | Brandenburg and Poland sign unity of Bromberg |
