| February 3 | Philadelphia establishes a "pesthouse" to quarantine immigrants |
| February 8 | Comet C/1743 C1 approaches within 0.0390 AUs of Earth |
| March 5 | 1st U.S. religious journal, The Christian History, published, Boston |
| March 14 | 1st American town meeting (Boston's Faneuil Hall) |
| March 23 | English premiere of Handel's "Messiah" |
| March 23 | George Frideric Handel's oratorio "Messiah" premieres in London |
| June 27 | English defeat French at Dettingen |
| July 18 | 1st half-page newspaper ad is published (New York Weekly Journal) |
| August 10 | Earliest recorded prize fighting rules formulated |
| August 14 | Prussian army occupies Saksen, beginning 2nd Silezian War |
| August 16 | Earliest boxing code of rules formulated in England (Jack Broughton) |
| August 17 | Sweden and Russia sign peace treaty |
| September 2 | England/Austria/Savoye-Sardinia sign Treaty of Worms |
| September 13 | England, Austria and Savoye-Sardinia sign Treaty of Worms |
