| February 17 | Messier catalogs M83 (spiral galaxy in Hydra) |
| February 25 | 1st Bank of U.S. chartered |
| March 3 | 1st internal revenue act (taxing distilled spirits and carriages) |
| March 3 | Congress establishes U.S. Mint |
| March 4 | 1st Jewish member of U.S. Congress, Israel Jacobs (PA), takes office |
| March 4 | President Washington calls the U.S. Senate into its 1st special session |
| March 4 | Vermont admitted as 14th state (1st addition to the 13 colonies) |
| March 10 | John Stone, Concord, Massachusetts, patents a pile driver |
| March 10 | Pope condemns France's Civil Constitution of the clergy |
| March 11 | Samuel Mulliken, Philadelphia, is 1st to obtain more than 1 U.S. patent |
| March 21 | Captain Hopley Yeaton of New Hampshire becomes 1st commissioned officer in Revenue Cutter Service |
| June 20 | King Louis XVI caught trying to escape French Revolution |
| June 21 | Fleeing French King Louis XVI and family captured at Varennes-en-Argonne |
| July 5 | Jose Maria Narvaez discovers Point Grey (now Vancouver BC) |
| August 2 | Samuel Briggs and his son, patent nail-making machine |
| August 4 | Austria and Turkey sign Peace of Sistova |
| August 19 | Benjamin Banneker published his 1st Almanac |
| August 20 | Danish navigator Vitus Jonas Bering discovers Alaska |
| August 22 | Haitian Slave Revolution begins under voodoo priest Boukman |
| August 26 | John Fitch grants U.S. patent for his working steamboat |
| September 3 | French Constitution passed by French National Assembly |
| September 6 | Mozarts opera "La Clemenza di Tito," premieres in Prague |
| September 13 | France's King Louis XVI accepts constitution |
| September 30 | Mozart's opera "Magic Flute" premieres in Vienna |
| October 1 | 1st session of new French legislative assembly |
| October 1 | Dutch prince Willem Frederik marries his niece princess Frederika Louise Wilhelmina of Prussia |
| November 3 | Battle at Wabash: indians assault general St. Clair/killed 637 soldiers |
| November 15 | 1st Catholic college in U.S., Georgetown, opens |
| December 4 | Britain's Observer, oldest Sunday newspaper in world, 1st published |
| December 12 | Bank of U.S. opens |
| December 15 | 1st U.S. law school established at University of Pennsylvania |
| December 15 | Bill of Rights ratified when Virginia gave its approval |
| December 17 | New York City traffic regulation creates 1st 1-way street |