| January 8 | Cape colony becomes English colony |
| January 8 | Lewis and Clark find skeleton of 105' blue whale in Oregon |
| January 10 | Dutch in Capetown surrender to British |
| January 12 | French evacuate Vienna |
| January 19 | Britain occupies Cape of Good Hope |
| January 30 | Prussia takes possession of Hanover |
| March 23 | Lewis and Clark reach Pacific coast |
| April 5 | Isaac Quintard patents apple cider |
| June 5 | 1st trotter to break 3 minute mile, Yankee |
| June 5 | Batavian Republic becomes Kingdom of Holland |
| June 24 | English under commodore Popham/col Beresford reach Buenos Aires |
| June 27 | Buenos Aires captured by British |
| July 3 | Michael Keens exhibits 1st cultivated strawberry |
| July 15 | Zebulon Pike began his journey to explore the Southwest |
| September 2 | A side of Rossberg Peak collapses into Goldau Valley, Switzerland, kills 500 |
| September 23 | Lewis and Clark return to St. Louis from Pacific Northwest |
| October 7 | Carbon paper patented in London by inventor Ralph Wedgewood |
| October 8 | British forces lay siege to French port of Boulogne using Congreve rockets, invented by Sir William Congreve |
| October 14 | Battle of Auerstadt-French beat Prussians |
| November 15 | 1st U.S. college magazine, Yale Literary Government, publishes 1st issue |
| November 15 | Explorer Zebulon Pike sights Pikes Peak (Colorado) |
| November 21 | Decree of Berlin: Emperor Napoleon I bans all trade with England |
