| January 1 | Curacao is taken by English, until March, 1816 |
| January 12 | Gunpowder-ship explodes in Leiden, Netherlands, 150 die |
| January 20 | Napoleon convenes great Sanhedrin, Paris |
| January 28 | London's Pall Mall is 1st street lit by gaslight |
| February 8 | Napoleon defeats Russians in battle of Eylau |
| February 9 | French Sanhedrin convened by Napoleon |
| February 10 | U.S. Coast Survey authorized by Congress |
| February 19 | British squadron under Admiral Duckworth forces passage of Dardanelle |
| February 19 | Vice President Aaron Burr arrested in Alabama for treason; later found innocent |
| February 24 | 17 die and 15 wounded in a crush to witness execution of Holloway, Heggerty and Elizabeth Godfrey in England |
| March 2 | Congress bans slave trade effective January 1, 1808 |
| March 5 | 1st performance of Ludwig von Beethoven's 4th Symphony in B |
| March 25 | 1st railway passenger service began in England |
| March 25 | British Parliament abolishes slave trade |
| March 25 | George Canning becomes British minister of Foreign affairs |
| May 22 | Former Vice President Aaron Burr is tried for treason in Richmond Virginia (acquitted) |
| May 22 | Townsend Speakman 1st sells fruit-flavored carbonated drinks in Philadelphia |
| June 22 | British board USS Chesapeake, a provocation leading to War of 1812 |
| June 26 | Lightning hits gunpowder warehouse in Luxembourg; 230 die |
| June 28 | British troops lands at Ensenada, Argentina |
| July 7 | France, Russia and Prussia sign Peace of Tilsit |
| August 17 | Robert Fulton's steamboat Clermont begins 1st trip up Hudson River |
| September 1 | Aaron Burr acquitted of charges of plotting to set up an empire |
| September 4 | Robert Fulton begins operating his steamboat |
| September 14 | Aaron Burr acquitted of a misdemeanor charge |
| December 22 | Congress passes Embargo Act, to force peace between Britain and France |