| January 7 | 2nd Bank of U.S. opens |
| January 18 | San Martin leads a revolutionary army over Andes |
| January 22 | English freighter Diana sinks off Malaysia |
| January 25 | Rossini's opera "La Cenerentola" premieres in Rome |
| January 31 | Franz Grillparzer's "Die Ahnfrau," premieres in Vienna |
| February 5 | 1st U.S. gas co incorporated, Baltimore (coal gas for street lights) |
| February 17 | Baltimore is the 1st U.S. city lit by gas |
| March 2 | 1st Evangelical church building dedicated, New Berlin, Penn |
| March 3 | Mississippi Territory is divided into Alabama Territory and Mississippi |
| March 25 | Tsar Alexander I recommends formation of Society of Israeli Christians |
| April 15 | 1st American school for the deaf opens in Hartford, Connecticut |
| April 17 | 1st U.S. school for deaf (Hartford, Conn) |
| April 22 | Curacao prohibits use of white paint due to fierce sunlight |
| May 15 | Ambonese uprising against Dutch authority, under T Matulesia |
| May 16 | Mississippi River steamboat service begins |
| June 12 | Karl Drais von Sauerbronn demonstrates bicycle course |
| June 24 | 1st coffee planted in Hawaii on Kona coast |
| July 4 | Construction on Erie Canal begins |
| July 12 | 1st flower show held, Dannybrook, County Cork, Ireland |
| August 18 | Gloucester, Massachusetts, newspapers tells of wild sea serpent seen offshore |
| September 9 | Alexander Lucius Twilight, probably 1st black to graduate from U.S. college, receives BA degree at Middlebury College |
| September 22 | John Quincy Adams becomes Secretary of State |
| October 9 | University of Gent officially opens |
| October 20 | 1st Mississippi "Showboat," leaves Nashville on maiden voyage |
| November 20 | 1st Seminole War begins in Florida |
| November 25 | 1st sword swallower in U.S. performs (New York City) |
| November 27 | U.S. soldiers attack Florida Indian village, beginning Seminole War |
| December 10 | Mississippi admitted as 20th state |
| December 16 | Leaders of Molukkas uprising hanged in Ambon |
| December 30 | 1st coffee planted in Hawaii (Kona) |
