| January 17 | Mexico permits Moses Austin and 300 U.S. families to settle in Texas |
| January 21 | Paramaribo Suriname catches fire, 4 die |
| January 28 | Bellingshausen discovers Alexander Island off Antarctica |
| February 12 | Mercantile Library of City of New York opens |
| February 22 | Spain sells eastern Florida to United States for $5 million |
| February 23 | College of Apothecaries organized in Phil; 1st U.S. pharmacy college |
| February 24 | Mexico gains independence from Spain |
| March 5 | Monroe is 1st President inaugurated on March 5th, because 4th was Sun |
| March 14 | African Methodist Episcopal Zion Church founded (New York) |
| March 25 | Greece gains independence from Turkey (National Day) |
| March 26 | Franz Grillparzer's "Das Goldene Vliess," premieres in Vienna |
| May 30 | James Boyd patents Rubber Fire Hose |
| May 31 | Cathedral of Assumption of Blessed Virgin Mary, 1st U.S. Catholic cathedral, is dedicated in Baltimore |
| June 18 | Opera "Der Freischutz" is produced (Berlin) |
| June 21 | African Methodist Episcopal Zion (AMEZ) Church organizes (New York City) |
| June 23 | Dutch troops conquer Palembang |
| June 24 | Battle of Carabobo; Bolivar defeats royalists outside of Caracas |
| July 17 | Spain cedes Florida to U.S. |
| July 28 | Peru declares independence from Spain (National Day) |
| August 4 | 1st edition of Saturday Evening Post (publishes until 1969) |
| August 6 | 1st edition of "Courrier of Pays-Bas" newspaper published in Brussels |
| August 10 | Missouri admitted as 24th U.S. state |
| August 19 | Failed liberal coup against French King Louis XVIII |
| August 23 | Mexico declares independence |
| September 1 | 1st colonies along Santa Fe Trail |
| September 15 | Costa Rica El Salvador Guatemala Honduras and Nicaragua gain independ |
| September 27 | Mexican Empire declares its independence |
| September 27 | Revolutionary forces occupy Mexico City as Spanish withdraw |
| November 9 | 1st U.S. pharmacy college holds 1st classes, Philadelphia |
| November 28 | Panama declares independence from Spain |
| December 1 | Santo Domingo (Dominican Rep) proclaims independence from Spain |
| December 17 | Kentucky abolishes debtors prisons |
| December 28 | Naples: Gioacchini Rossini moves to Bologna |
