| January 27 | President Monroe appoints 1st U.S. ambassadors to South America |
| February 2 | Rossini's opera "Semiramide" premieres in Venice |
| February 20 | English Captain James Weddell reaches 74 degrees 15' S, 1520 km from S pole |
| March 11 | 1st normal school in U.S. opens, Concord Academy, Concord, Vt |
| April 22 | Baltic Club (Exchange) forms in London |
| April 22 | R. J. Tyers patents roller skates |
| April 24 | Eugene Scribes "Le Menteur Veridique," premieres in Paris |
| May 8 | "Home Sweet Home" 1st sung (London) |
| May 10 | 1st steamboat to navigate the Mississippi River arrives at Ft. Snelling |
| June 16 | King Willem I opens shipyard at Rotterdam-Antwerp |
| July 1 | 9th Postmaster General: John McLean of Ohio takes office |
| July 1 | United Provinces of Central America gain independence from Mexico |
| July 14 | Switzerland signs boundaries for fugitives |
| September 10 | Simon Bolivar named president of Peru |
| September 21 | Moroni 1st appears to Joseph Smith, according to Smith |
| October 5 | Weber visits Beethoven |
| October 12 | Charles Macintosh of Scotland begins selling raincoats (Macs) |
| November 12 | Great North Holland Canal (Amsterdam) opens |
| December 2 | President James Monroe declares his "Monroe Doctrine" |
| December 13 | Gioacchino Rossini arrives in London |
| December 19 | Georgia passes 1st U.S. state birth registration law |
| December 20 | Franz Schuberts "Ballet-Musik aus Rosamunde," premieres in Vienna |
| December 23 | "Visit from St. Nicholas" by C Moore published in Troy (NY) Sentinel |