| January 1 | Baron Van der Capellen resigns as governor of Dutch-Indies |
| February 11 | London University founded |
| February 13 | American Temperance Society, forms in Boston |
| February 28 | M Biela, an Austrian officer, discovers Biela's Comet |
| March 4 | 1st U.S. Railroad chartered, Granite Railway in Quincy, Massachsetts |
| March 14 | General Congress of South American States assembles at Panama |
| March 21 | Beethoven's Quartet #13 in B flat major (Op 130) premiered in Vienna |
| April 1 | Samuel Mory patents internal combustion engine |
| April 12 | Weber's opera "Oberon," premieres in London |
| April 23 | Missolonghi captured by Turks |
| June 10 | Sultan Mahmud II rebellious elite corp, slaughter 20,000 in Turkey |
| June 20 | Siam/England sign trade/peace treaty |
| July 26 | Vilnus Lithuanian riots cause death of many Jews |
| July 30 | Java prince Dipo Negoro surprise attacks Dutch colony, 82 killed |
| August 19 | Canada Co chartered to colonize Upper Canada (Ontario) |
| August 22 | Colonies under Jedediah Strong Smith move near Salt Lake Utah |
| August 24 | Netherland's South Willems Port (Bosch-Luik) opens |
| September 3 | USS Vincennes leaves New York to become 1st warship to circumnavigate globe |
| October 7 | Granite Railway (1st chartered railway in U.S.) begins operations |
| November 15 | Dutch Business Me gets monopoly on opium trade in Java/Madura |
| November 27 | John Walker invents friction match in England |
