| January 1 | Bulgaria joins the European Union |
| January 1 | Romania joins the European Union |
| January 1 | Slovenia begins using the Euro as it's currency |
| January 3 | Gerald Ford is buried in Grand Rapids, Michigan |
| January 4 | Nancy Pelosi is elected Speaker of the House, by a vote of 233-202 |
| January 9 | Apple Computer unveils the revolutionary iPhone |
| January 11 | Vietnam becomes the 150th member of the World Trade Organization |
| January 30 | Microsoft releases Windows Vista |
| February 25 | 79th Academy Awards hosted by Ellen DeGeneres in Hollywood |
| February 25 | 'The Departed' wins Best Picture at the Academy Awards |
| March 6 | Mega Millions has the highest lottery jackpot ever, $370 million dollars |
| April 2 | 8.1 earthquake triggers tsunami in the Solomon Islands |
| May 6 | Nicolas Sarkozy wins the French presidential election |
| June 8 | Space Shuttle Atlantis, STS-117, begins mission |
| July 4 | BBC journalist Alan Johnston is freed by Palestinian kidnappers |
| July 8 | Boeing launches it's newest aircraft, the Boeing 787 Dreamliner |
| July 16 | Earthquake in Japan damages nuclear power plan releasing 300 gallons of radioactive water |
| August 14 | Multiple suicide bombings kill over 550 people in Qahtaniya, Iraq |
| August 15 | 8.0 Earthquake in Peru kills over 500 people, injures over 1,500 |
| September 13 | Burj Dubai becomes the world's largest structure |
| October 8 | Marion Jones gives up 5 Olympic medals after admitting to using performance-enhancing drugs |
| November 5 | Writers Guild of American goes on strike |
| November 14 | 7.7 Earthquake in northern Chile |
| December 27 | Benazir Bhutto is assassinated by a bomb blast in Rawalpindi, Pakistan |