February 12 Santiago, Chile founded (or Feb 24) February 24 Santiago, Chile founded by Pedro de Valvidia (or 2/12) March 18 Hernan de Soto observes 1st recorded flood in America (Mississippi R) April 4 Ignatius of Loyola becomes 1st superior-general of Jesuits May 8 Hernando de Soto discovers Mississippi River June 14 Duke Willem van Gulik of Gelre marries Jeanne d'Albret June 18 Irish parliament selects Henry VIII as king of Ireland August 26 Turkish sultan Suleiman occupies Buda/annexes Hungary October 31 Michelangelo Buonarroti's paints "last judgement" in Sistine Chapel November 9 Queen Catharine Howard confined in London Tower December 29 Isabella of Poland and King Ferdinand of Austria sign Treaty of Gyalu